An Israeli airstrike in the city of Rafah on Saturday ended the joy of a Palestinian woman with her twins, whom she gave birth to after three rounds of in vitro fertilization, spanning 10 years, according to "Associated Press".

The Israeli airstrike hit the home of Rania Abu Anza's family late on Saturday, killing her five-month-old twins "Wisam and Naeem," her husband, and 11 other relatives.

The Israeli airstrike left nine other people missing under the rubble, according to survivors and local health officials.

Rania Abu Anza woke up around 10 p.m. to breastfeed her son Naeem, then placed him on one of her arms and her daughter Wisam on the other arm, while her husband was sleeping beside them, before the explosion happened an hour and a half later.

Abu Anza said on Sunday, crying as she placed her child's mattress on her chest: "They all died, and their father took them and left me behind."

According to the agency, Israeli airstrikes have been hitting crowded family homes in Rafah, which Israel declared a safe zone last October, "but it has now become the next target for its ground attack."

Strikes often come without warning, usually at midnight, according to Associated Press.

Israel says it tries to avoid harming civilians and blames Hamas for their deaths, "because it spreads fighters, tunnels, and rocket launchers in densely populated residential areas."

The Israeli military rarely comments on individual strikes that often kill women and children. It did not immediately comment on this strike, according to the agency.

Dr. Marwan Al-Hamas, director of the hospital to which the bodies were transferred, said, "Among the 14 killed in the Abu Anza home, there are six children and four women."

He pointed out that "Rania lost, in addition to her husband and children, her sister, her nephew, her pregnant cousin, and other relatives."

Farouk Abu Anza, a relative of Rania, said, "About 35 civilians, most of them children, were residing in the house, some displaced from other areas."

Rania and her husband Wisam spent a decade trying to have a child. Two rounds of IVF failed, but after the third round early last year, Rania found out she was pregnant and gave birth to the twins on October 13 last year.

She added that her husband Wisam, who worked daily wages, was very proud to the extent that he insisted on naming his daughter after him.

She said, "I was never satisfied with them... I swear I was never enough for them."

On last October 7, armed militants led by Hamas stormed southern Israel in a surprise attack, resulting in about 1,200 deaths, most of them civilians, and the capture of about 250 hostages, including children and newborns, according to Israeli authorities.

Israel responded with a retaliatory campaign that led to the killing of more than 30,000 Palestinians, according to the Gaza Ministry of Health.

About 80% of Gaza's 2.3 million residents have fled their homes, while a quarter of the population faces the specter of famine.

The Ministry said last month that more than 12,300 Palestinian children were killed in the war, about 43% of the total number of deaths. The ministry does not differentiate between civilians and fighters in its statistics.

Humanitarian workers say, "The war has turned life for the children who survived into hell, as some of them in northern Gaza are out of reach of care."

The UNICEF Regional Director for the Middle East, Adele Khadr, said in a statement on Sunday, "The feeling of helplessness and despair among parents and doctors when they realize that lifesaving aid is out of reach is unbearable."

She added, "But worse than that are the screams of pain from those children who are slowly dying before the eyes of the world."

Until Saturday, the Abu Anza family was relatively lucky, as Rafah survived the massive destruction that hit northern Gaza and southern Khan Yunis city.

But Israel said, "The Rafah crossing will be next, and nearly 1.5 million people who have taken refuge there will be transferred, without specifying their location."

Rania said, "We have no rights. I have lost the dearest people to me, and I do not want to live here; I want to leave this country because I am tired of this war."